What an odd question,,but then when you think about it, a good question,,so does it make a difference, yes if the nut is on the clutch lever side then if an wheel could possibly seize and grab a wheel bolt then I would unwind it, but then if it was the other way then a serious lock up would occur..
Well I think not,,just put the correct washers,spacers,anti twist plates etc on in the right place and bobs your uncle