Sprocket advice

[Sam13]

Hi all.

Have any of you changed front and rear sprockets to +/- number of teeth.

I'm interested to know how acceleration vs top end is affected.

I'm not overly concerned with top end speed as you can't really make good use of it on the road (legally) but would make use of better acceleration.

Does it make that much difference ? Any figures to back up?
Best combinations ?

Thanks in advance