While cleaning the bike over the weekend (I do it every 6 months, even when it doesn't need it), I noticed that the teeth on the inside of the rear socket were bright and shiney while the outside of the teeth were their normal greyish brown. Out of interest, I pulled the front sprocket cover and noticed the same thing. The hooks showing normal wear for their age but the outside of the teeth are bright and shiney with clear wear marks and no sign on wear on the inside.
I don't think this is simply the rear wheel being incorrectly aligned after adjusting the chain, but I can't think what else could cause it.